AustralieFrV1, Main, Exploration, bibRecord, 008100

Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History

Identifieur interne : 008100 ( Main/Exploration ); précédent : 008099; suivant : 008101

Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History

Auteurs : Carole Dufouil [France] ; Ophélia Godin [France] ; John Chalmers [Australie] ; Oghuzan Coskun [France] ; Stephen Macmahon [Australie] ; Nathalie Tzourio-Mazoyer [France] ; Marie-Germaine Bousser [France] ; Craig Anderson [Australie] ; Bernard Mazoyer [France] ; Christophe Tzourio [France]

Source :

Stroke : (1970) [ 0039-2499 ] ; 2009.

RBID : Pascal:09-0260330

Descripteurs français

Pascal (Inist)
- Trouble cognitif, Pathologie cérébrovasculaire, Démence, Accident cérébrovasculaire, Hypertension artérielle, Pathologie du système nerveux, Encéphale, Substance blanche, Hyperintensité, Homme, Imagerie RMN.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cerebrovascular disease, Cognitive disorder, Dementia, Encephalon, Human, Hyperintensity, Hypertension, Nervous system diseases, Nuclear magnetic resonance imaging, Stroke, White matter.

Abstract

Background and Purpose-Cerebral white matter hyperintensities (WMHs) are believed to be the consequence of small vessel disease, and it is uncertain whether their extent predicts the risk of dementia in patients with vascular disease history. Method-Brain MRI was performed in 226 participants of the PROGRESS study. WMH severity was assessed using a visual rating scale. During follow-up, patients were classified for incident severe cognitive deterioration (including dementia) using standard criteria. Results-Over 4-year follow-up, the incidence of severe cognitive deterioration ranged from 1.1 to 9.1 per 100 person-years in patients with respectively no or severe WMHs at baseline. In multivariable analysis, incident severe cognitive deterioration was associated with baseline severe WMHs (odds ratio=7.7, P<0.005). Conclusion-Higher WMH load is a strong predictor of dementia and cognitive decline in patients with cerebrovascular disease history.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 002D58
to stream PascalFrancis, to step Curation: 003262
to stream PascalFrancis, to step Checkpoint: 002856
to stream Main, to step Merge: 008825
to stream Main, to step Curation: 008100

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History</title>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, U708</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Pierre et Marie Curie-Paris6</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Godin, Ophelia" sort="Godin, Ophelia" uniqKey="Godin O" first="Ophélia" last="Godin">Ophélia Godin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, U708</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Pierre et Marie Curie-Paris6</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The George Institute for International Health</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coskun, Oghuzan" sort="Coskun, Oghuzan" uniqKey="Coskun O" first="Oghuzan" last="Coskun">Oghuzan Coskun</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CHU de Caen</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The George Institute for International Health</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzourio Mazoyer, Nathalie" sort="Tzourio Mazoyer, Nathalie" uniqKey="Tzourio Mazoyer N" first="Nathalie" last="Tzourio-Mazoyer">Nathalie Tzourio-Mazoyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>CNRS, CEA UMR6232</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Université de Caen Basse-Normandie</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
<settlement type="city">Caen</settlement>
</placeName>
<orgName type="university">Université de Caen Basse-Normandie</orgName>
</affiliation>
</author>
<author><name sortKey="Bousser, Marie Germaine" sort="Bousser, Marie Germaine" uniqKey="Bousser M" first="Marie-Germaine" last="Bousser">Marie-Germaine Bousser</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>AP-HP, Hôpital Lariboisière , Service de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The George Institute for International Health</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, U708</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CHU de Caen</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>CNRS, CEA UMR6232</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Université de Caen Basse-Normandie</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
<settlement type="city">Caen</settlement>
</placeName>
<orgName type="university">Université de Caen Basse-Normandie</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Institut Universitaire de France</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, U708</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Pierre et Marie Curie-Paris6</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>AP-HP, Hôpital Lariboisière , Service de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0260330</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0260330 INIST</idno>
<idno type="RBID">Pascal:09-0260330</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002D58</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003262</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002856</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002856</idno>
<idno type="wicri:doubleKey">0039-2499:2009:Dufouil C:severe:cerebral:white</idno>
<idno type="wicri:Area/Main/Merge">008825</idno>
<idno type="wicri:Area/Main/Curation">008100</idno>
<idno type="wicri:Area/Main/Exploration">008100</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History</title>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, U708</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Pierre et Marie Curie-Paris6</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Godin, Ophelia" sort="Godin, Ophelia" uniqKey="Godin O" first="Ophélia" last="Godin">Ophélia Godin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, U708</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Pierre et Marie Curie-Paris6</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The George Institute for International Health</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coskun, Oghuzan" sort="Coskun, Oghuzan" uniqKey="Coskun O" first="Oghuzan" last="Coskun">Oghuzan Coskun</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CHU de Caen</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The George Institute for International Health</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzourio Mazoyer, Nathalie" sort="Tzourio Mazoyer, Nathalie" uniqKey="Tzourio Mazoyer N" first="Nathalie" last="Tzourio-Mazoyer">Nathalie Tzourio-Mazoyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>CNRS, CEA UMR6232</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Université de Caen Basse-Normandie</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
<settlement type="city">Caen</settlement>
</placeName>
<orgName type="university">Université de Caen Basse-Normandie</orgName>
</affiliation>
</author>
<author><name sortKey="Bousser, Marie Germaine" sort="Bousser, Marie Germaine" uniqKey="Bousser M" first="Marie-Germaine" last="Bousser">Marie-Germaine Bousser</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>AP-HP, Hôpital Lariboisière , Service de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>The George Institute for International Health</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, U708</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CHU de Caen</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>CNRS, CEA UMR6232</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Université de Caen Basse-Normandie</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
<settlement type="city">Caen</settlement>
</placeName>
<orgName type="university">Université de Caen Basse-Normandie</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Institut Universitaire de France</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm, U708</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Pierre et Marie Curie-Paris6</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>AP-HP, Hôpital Lariboisière , Service de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Stroke : (1970)</title>
<title level="j" type="abbreviated">Stroke : (1970)</title>
<idno type="ISSN">0039-2499</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Stroke : (1970)</title>
<title level="j" type="abbreviated">Stroke : (1970)</title>
<idno type="ISSN">0039-2499</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrovascular disease</term>
<term>Cognitive disorder</term>
<term>Dementia</term>
<term>Encephalon</term>
<term>Human</term>
<term>Hyperintensity</term>
<term>Hypertension</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Stroke</term>
<term>White matter</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble cognitif</term>
<term>Pathologie cérébrovasculaire</term>
<term>Démence</term>
<term>Accident cérébrovasculaire</term>
<term>Hypertension artérielle</term>
<term>Pathologie du   système nerveux</term>
<term>Encéphale</term>
<term>Substance blanche</term>
<term>Hyperintensité</term>
<term>Homme</term>
<term>Imagerie RMN</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background and Purpose-Cerebral white matter hyperintensities (WMHs) are believed to be the consequence of small vessel disease, and it is uncertain whether their extent predicts the risk of dementia in patients with vascular disease history. Method-Brain MRI was performed in 226 participants of the PROGRESS study. WMH severity was assessed using a visual rating scale. During follow-up, patients were classified for incident severe cognitive deterioration (including dementia) using standard criteria. Results-Over 4-year follow-up, the incidence of severe cognitive deterioration ranged from 1.1 to 9.1 per 100 person-years in patients with respectively no or severe WMHs at baseline. In multivariable analysis, incident severe cognitive deterioration was associated with baseline severe WMHs (odds ratio=7.7, P<0.005). Conclusion-Higher WMH load is a strong predictor of dementia and cognitive decline in patients with cerebrovascular disease history.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Basse-Normandie</li>
<li>Nouvelle-Galles du Sud</li>
<li>Région Normandie</li>
<li>Île-de-France</li>
</region>
<settlement><li>Caen</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Caen Basse-Normandie</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
</region>
<name sortKey="Bousser, Marie Germaine" sort="Bousser, Marie Germaine" uniqKey="Bousser M" first="Marie-Germaine" last="Bousser">Marie-Germaine Bousser</name>
<name sortKey="Coskun, Oghuzan" sort="Coskun, Oghuzan" uniqKey="Coskun O" first="Oghuzan" last="Coskun">Oghuzan Coskun</name>
<name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<name sortKey="Godin, Ophelia" sort="Godin, Ophelia" uniqKey="Godin O" first="Ophélia" last="Godin">Ophélia Godin</name>
<name sortKey="Godin, Ophelia" sort="Godin, Ophelia" uniqKey="Godin O" first="Ophélia" last="Godin">Ophélia Godin</name>
<name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<name sortKey="Tzourio Mazoyer, Nathalie" sort="Tzourio Mazoyer, Nathalie" uniqKey="Tzourio Mazoyer N" first="Nathalie" last="Tzourio-Mazoyer">Nathalie Tzourio-Mazoyer</name>
<name sortKey="Tzourio Mazoyer, Nathalie" sort="Tzourio Mazoyer, Nathalie" uniqKey="Tzourio Mazoyer N" first="Nathalie" last="Tzourio-Mazoyer">Nathalie Tzourio-Mazoyer</name>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
</region>
<name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name>
<name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008100 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008100 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:09-0260330
   |texte=   Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History

Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri